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A group of protesters who call themselves "mutants" have taken over the inner city streets of a large city. They dress weird to try and show the effects of toxic poisoning. One of the mutants, Splatter, has really been affected. A group of fraternity boys decide to go into the mutant territory and kidnap one of the mutants as a prank. They inadvertently get framed for the murder of the mutant leader and are hunted through the abandoned buildings and dark streets by a crazed Splatter and his gang.